Тип публикации: статья из журнала (материалы конференций, опубликованные в журналах)
Конференция: International Symposium on Health Aspects of Environmental and Occupational Pesticide Exposure; DUSSELDORF, GERMANY; DUSSELDORF, GERMANY
Год издания: 1999
Идентификатор DOI: 10.1016/S0378-4274(99)00032-6
Ключевые слова: lymphocytes; interleukin-4; interferon-gamma; histamine liberation; pyrethroids; piperonyl-butoxide
Аннотация: Synthetic pyrethroids are increasingly used as insecticides and are claimed to have a relatively low human toxicity. The aim of this study was to examine the in vitro effects of the synthetic pyrethroid S-bioallethrin alone and in combination with the common synergist piperonyl-butoxide (PBO) on human blood lymphocytes and basophilПоказать полностьюs in atopic individuals and non-atopic control subjects. S-bioallethrin and PBO also caused inhibition of lymphocyte proliferation (MTT-test) after a 72-h culture period in a concentration dependent manner. In contrast to the MTT-measurements the combined agents are more effective in inhibiting interleukin-4 (IL-4)- and interferon-gamma (IFN-gamma)-production. The regulatory IL-4/IFN-gamma balance showed a significant difference between atopic and nonatopic subjects after a culture period of 24-48 h in the presence of micromolar S-bioallethrin (P
Журнал: TOXICOLOGY LETTERS
Выпуск журнала: Vol. 107, Is. 1-3
Номера страниц: 65-74
ISSN журнала: 03784274
Место издания: CLARE
Издатель: ELSEVIER SCI IRELAND LTD