Тип публикации: статья из журнала
Год издания: 2023
Идентификатор DOI: 10.1007/s10600-023-04183-5
Ключевые слова: allobetulin, thiadiazole
Аннотация: Allobetulin is a pentacyclic oleanane-type triterpenoid that occurs among triterpene compounds of birch bark and is easily produced from betulin via isomerization under acidic conditions [1, 2] and heating in the presence of thiourea [3]. The advantage of transforming allobetulin is completely obvious if its biological activity is Показать полностьюconsidered [4,5,6]. Allobetulin possesses potent inhibitory activity against influenza B virus [6] while 28-oxoallobetulin is an effective inhibitor of influenza H7N1 virus replication [7]. The thiadiazole moiety is known to be included in the structure of cephalosporin antibiotics [8]. The synthesis of 1,2,3-thiadiazoles based on natural compounds can lead to the discovery of new biologically active compounds. Compounds with a 1,2,3-thiadiazole condensed with an A-nor-3-ketone [9] and with betulonic acid methyl ester [10] have been synthesized. Herein, the synthesis of a 1,2,3-thiadiazole from allobetulone (1) is reported for the first time.
Журнал: Chemistry of Natural Compounds
Выпуск журнала: Т.59, №5
Номера страниц: 1015-1016
ISSN журнала: 00093130
Место издания: Ташкент
Издатель: Springer New York Consultants Bureau