Тип публикации: статья из журнала
Год издания: 2025
Идентификатор DOI: 10.1134/S0022093025010211
Ключевые слова: Mouse kidney, ferrihydrite nanoparticles, oral administration, morphometric parameters, histological examination
Аннотация: The unique physical, chemical and magnetic properties of iron oxide nanoparticles (INPs) open up wide prospects for the use of nanomaterials in the diagnosis and therapy of various diseases. Despite the high interest from the scientific community, the mechanism of the effect of INPs on the physiology of living organisms has not beeПоказать полностьюn fully investigated. This is not least due to the fact that the toxicity of nanoparticles depends on multiple factors, including their size, method of synthesis, and the presence of a shell. This work was aimed to study the effect of synthetic and biogenic ferrihydrite INPs on the mouse kidney morphology, depending on the method of their synthesis and the presence of a polysaccharide shell after oral administration. The animals (<i>n</i> = 55) were allocated into 3 groups: group 1 (<i>n</i> = 15)—control mice, fed food without INP supplementation; group 2 (<i>n</i> = 20)—experimental mice, fed food supplemented with synthetic uncoated INPs; group 3 (<i>n</i> = 20)—experimental mice, fed food supplemented with encapsulated biogenic INPs. The biological material (mouse kidney) was sampled for standard histological examination a day before the onset of feeding with INP supplementation, as well as on days 22 and 36 after that. It was found that long-term administration of both synthetic and biogenic INPs was accompanied by hemodynamic disorders in the kidney, as well as dystrophic and necrotic alterations in renal parenchymal cells, leading to the development of renal failure. Biogenic INPs displayed a highest reactivity, which is probably due to the presence of a polysaccharide shell and the crystalline structure of the ferrihydrite core.
Журнал: Journal of Evolutionary Biochemistry and Physiology
Выпуск журнала: Т. 61, № 1
Номера страниц: 261-272
ISSN журнала: 00220930
Место издания: Moscow
Издатель: Pleiades Publishing, Ltd.