Тип публикации: статья из журнала

Год издания: 2025

Идентификатор DOI: 10.1134/S1022795424701837

Ключевые слова: nonalcoholic fatty liver disease, Adiponutrin, <i>PNPLA3</i>, <i>UCP2</i>, <i>HFE</i>

Аннотация: The risk of development and progression of nonalcoholic fatty liver disease (NAFLD) and metabolic abnormalities associated with it is connected not only with lifestyle but also with hereditary factors. We studied the relationship of polymorphism markers of the <i>PNPLA3</i> (rs738409), <i>UCP2</i> (rs660339), and <i>HFE</i> (rs1800Показать полностью562, rs1800730, rs1799945) genes with metabolic changes depending on the clinical form of NAFLD. For this study, 116 patients diagnosed with NAFLD and steatosis and steatohepatitis were examined. An assessment of metabolic parameters and genotyping using hydrolysis probes were performed. Polymorphism rs738409 is associated with the most pronounced changes in metabolic parameters in patients with steatohepatitis; polymorphic loci rs1800730 and rs660339 are associated only with dyslipidemia in patients with steatosis and patients with steatohepatitis.

Журнал: Russian Journal of Genetics

Выпуск журнала: Т.61, №4

Номера страниц: 435-443

ISSN журнала: 10227954

Место издания: Moscow

Издатель: Pleiades Publishing, Inc.

• Smirnova O.V. (Siberian Federal University)
• Lagutinskaya D.V. (Federal Research Center Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences—Scientific Research Institute of Medical Problems of the North)
• Kasparov E.V. (Federal Research Center Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences—Scientific Research Institute of Medical Problems of the North)

• Ядро РИНЦ (eLIBRARY.RU)