Тип публикации: статья из журнала

Год издания: 2025

Идентификатор DOI: 10.3390/bios15100644

Аннотация: <jats:p>Diabetes has become a global health challenge, driving the demand for innovative, non-invasive diagnostic technologies to improve glucose monitoring. Urinary glucose concentration, a reliable indicator of metabolic changes, provides a practical alternative for frequent monitoring without the discomfort of invasive methods. Показать полностьюIn this simulation-based study, we propose a novel asymmetric photonic structure that integrates Tamm plasmon polariton (TPP) modes and a cavity mode for high-precision refractive index sensing, with a conceptual focus on the potential detection of urinary glucose. The structure supports three distinct resonance modes, each with unique field localization. Both the TPP modes, confined at the metallic–dielectric interfaces, serve as stable references whose wavelengths are unaffected by refractive-index variations in human urine, whereas the cavity mode exhibits a redshift with increasing refractive index, enabling high responsiveness to analyte changes. The evaluation of sensing performance employs a sensitivity formulation that leverages either TPP mode as a reference and the cavity mode as a probe, thereby achieving dependable measurement and spectral stability. The optimized design achieves a sensitivity of 693 nm·RIU−1 and a maximum figure of merit of 935 RIU−1, indicating high detection resolution and spectral sharpness. The device allows both reflectance and transmittance measurements to ensure enhanced versatility. Moreover, the coupling between TPP and cavity modes demonstrates hybrid resonance, empowering applications such as polarization-sensitive or angle-dependent filtering. The figure of merit is analyzed further, considering resonance wavelength shifts and spectral sharpness, thus manifesting the structure’s robustness. Although this study does not provide experimental data such as calibration curves, recovery rates, or specificity validation, the proposed structure offers a promising conceptual framework for refractive index-based biosensing in human urine. The findings position the structure as a versatile platform for advanced photonic systems, offering precision, tunability, and multifunctionality beyond the demonstrated optical sensing capabilities.</jats:p>

Журнал: Biosensors

Выпуск журнала: Т. 15, № 10

Номера страниц: 644

ISSN журнала: 20796374

• Chou Hung-Che (Institute of Lighting and Energy Photonics, College of Photonics, National Yang Ming Chiao Tung University, Guiren Dist., Tainan 711010, Taiwan)
• Bikbaev Rashid G. (Institute of Engineering Physics and Radioelectronics, Siberian Federal University, Krasnoyarsk 660041, Russia)
• Timofeev Ivan V. (Institute of Engineering Physics and Radioelectronics, Siberian Federal University, Krasnoyarsk 660041, Russia)
• Lee Mon-Juan (Department of Chemical and Materials Engineering, National Kaohsiung University of Science and Technology, Sanmin Dist., Kaohsiung 807618, Taiwan)
• Lee Wei (Institute of Imaging and Biomedical Photonics, College of Photonics, National Yang Ming Chiao Tung University, Guiren Dist., Tainan 711010, Taiwan)

• Ядро РИНЦ (eLIBRARY.RU)